TP53 and cancer: E6 and E7 bind to tumor suppressor proteins p53 and pRb, marking them for degradation or blocking their binding sites, thereby preventing apoptosis and driving cellular proliferation.6, 7 With the knowledge of the genetic mechanism of this oncovirus, several siRNA sequences targeting the gene sequences that encode the E6 and E7 proteins have been developed, demonstrating rescue of the p53 and pRb tumor suppression pathways, resulting in cell cycle arrest and apoptosis in HPV‐infected cancer cells both in vitro and in vivo.