Mesenchymal stem cells (MSCs) have unique tumor‐targeting abilities given that they are recruited by tumors to enhance their proliferation.196, 197 These are mediated in part by direct cell‐cell interactions, suggesting utility of stem cell‐derived membrane for targeted delivery.198 “Nanoghosts” derived directly from MSC membranes were recently reported as a potential platform for targeted therapy of prostate cancer.199 The vesicles were loaded with soluble TRAIL (sTRAIL) by a physical extrusion method and were shown to retain their tumor‐binding properties both in vitro and in vivo. Here, TNFSF10 is linked to neoplasm.