RARA and chronic myelogenous leukemia, BCR-ABL1 positive: Aside from those patients with chronic myeloid leukemia (CML) induced by wild-type BCR-ABL fusion protein or those with acute promyelocytic leukemia (APL) caused by reciprocal chromosomal translocation of the retinoic acid receptor α (RARα) gene, most patients have a poor prognosis [2, 3].