CCR2 and myocardial infarction: Another group reported that blockade of CCR2 markedly reduced macrophage infiltration in ischemic lesions that results in attenuation of myocardial IR injury in mice via inhibition of macrophage-related oxidative stress and MMPs (50) They also demonstrated that macrophage infiltration into infarcted tissue was impaired in CCR2−/− mice after coronary ligation and the CCR2 deficiency ameliorates post-MI left ventricular (LV) remodeling via inhibition of macrophage-related MMPs (51).