The power of hiPSC-based systems to probe non-cell autonomous systems in Rett syndrome is underscored by recent studies demonstrating that MECP2-mutant astrocytes from patient-derived hiPSCs have deficiencies in microtubule-dependent vesicle transport, and that administration of Epothilone D, a microtubule stabilizing agent capable of crossing the blood brain barrier is sufficient to restore microtubule dynamics in these cells (Delépine et al., 2016). The gene discussed is MECP2; the disease is atypical Rett syndrome.