The introduction of a TCF/LEF-responsive luciferase reporter into hiPSC-derived NPCs permitting screening of a small pilot library of 1500 compounds, identifying a number of compounds that potentiate Wnt or lithium signaling (Zhao et al., 2012), with potential relevance to a number of psychiatric disorders (including schizophrenia and Fragile X) and many common antidepressants and antipsychotics. Here, HNF4A is linked to schizophrenia.