ALS: Selective removal of mSOD1 from microglia extends lifespan in mouse model of ALS.Rett Syndrome: murine Rett syndrome microglia have neurotoxic effects in co-cultured with hippocampal neurons. hiPSC derived microglia carrying MECP2 deletion are smaller potentially limiting their ability to perform critical immune surveillance functions. Here, MECP2 is linked to amyotrophic lateral sclerosis.