ALS: Selective removal of mSOD1 from microglia extends lifespan in mouse model of ALS.Rett Syndrome: murine Rett syndrome microglia have neurotoxic effects in co-cultured with hippocampal neurons. hiPSC derived microglia carrying MECP2 deletion are smaller potentially limiting their ability to perform critical immune surveillance functions. This evidence concerns the gene MECP2 and atypical Rett syndrome.