TTR and kidney disorder: In this scenario, emerging evidence demonstrate the important role for lysosomal proteases cathepsins (Cts) in the onset and progression of kidney disease (Svara et al., 2010; Moallem et al., 2011; Ozkayar et al., 2015; Cocchiaro et al., 2016; Fox et al., 2016; Yamamoto-Nonaka et al., 2016; Conley et al., 2017).