Other reports demonstrate a reduction of CtB activity during polycystic kidney disease (Schaefer et al., 1996; Hartz and Wilson, 1997; Tao et al., 2005), puromycin induced nephrosis (Huang et al., 1999), and rat and human diabetic nephropathy (Shechter et al., 1994; Grzebyk et al., 2013; Peres et al., 2013). The gene discussed is PCYT1B; the disease is diabetic kidney disease.