LRRK2 and Parkinson disease: Moreover, alpha-synuclein (aS) aggregation, as well as LRRK2 mutations, which cause PD, can be both involved in dysregulation of autophagic and endo-lysosomal pathways through different mechanisms, and are also associated with mitochondrial dysfunction (Niu et al., 2012; Papkovskaia et al., 2012; Nakamura, 2013; Yang et al., 2014).