GBA1 and Parkinson disease: Moreover, in many models and patients, GBA1 deficiencies were associated with aS accumulation and aggregation (Choi et al., 2011; Cullen et al., 2011; Osellame et al., 2013), establishing a solid link between the two genes and involving aS as a key element in GBA1-associated neurodegeneration in PD, likely through impairment of the autophagic-lysosomal pathway and mitochondrial dysfunction, possibly attributable to accumulation of dysfunctional mitochondria as a consequence of defective mitophagy.