RUNX1 and Down syndrome: Among the 21 patients with AML, 10 were classified as AML with recurrent genetic abnormalities (50) [biallelic mutation of CEBPA, n = 1; NPM1, n = 2; KMT2A rearrangement, n = 2; inv16 (p13.1q22), n = 2; t(8;21)(q22;q22.1), n = 1; RUNX1 mutation, n = 2], one patient had AML associated with Down syndrome, one patient had AML with myelodysplasia related changes, and the remaining nine patients had AML not otherwise specified.