In vivo, SChLAP1 has been shown to be implicated in tumor cell proliferation and metastasization, as evidenced by both the reduction of tumor growth kinetics and the decreased number and dimensions of metastatic sites as a consequence of the intracardiac injection of 22Rv1 cells with SChLAP1 knockdown in CB-17 SCID mice (41). This evidence concerns the gene SCHLAP1 and neoplasm.