SERPINE1 and melanoma: Although the authors did not undertake an unbiased astrocyte-specific profiling in their experiments gliosis-related genes such as Gfap, Cxcl10, Lcn-2, Serpina3n, Serpine1, and Timp-1 were significantly upregulated in the group of mice in which melanoma cells were coinjected together with astrocytes as compared to melanoma cells injected alone (51).