Although the authors did not undertake an unbiased astrocyte-specific profiling in their experiments gliosis-related genes such as Gfap, Cxcl10, Lcn-2, Serpina3n, Serpine1, and Timp-1 were significantly upregulated in the group of mice in which melanoma cells were coinjected together with astrocytes as compared to melanoma cells injected alone (51). Here, TIMP1 is linked to melanoma.