After adjusting for confounders, including age, diabetes, creatinine clearance, female gender, weight>60kg, smoke, C-reactive protein (CRP) >3mmol/l and LVEF, significant Δcystatin C (≥0.3 mg/dL or ≥10%) was not an independent risk factor for long-term mortality (HR=1.08, 95%CI, 0.34-3.43, P=0.902) (Figure 4). The gene discussed is CRP; the disease is diabetes mellitus.