CHFR promoter methylation was not associated with NSCLC stages, the frequency of CHFR promoter methylation in stage III/IV NSCLC was not significantly increased compared to stage I/II NSCLC, OR was 0.26, 95% CI 0.06–1.13, test for overall effect, Z = 1.79, p = 0.007 (Figure 5). This evidence concerns the gene CHFR and non-small cell lung carcinoma.