Comparing to non-neoplastic glandular cells (4.8%, 1/21) and adenoma tissue (5.3%, 2/38), the expression of p-LRP6 was much more intense in carcinoma with higher positive level (62.3%, 114/183), which displayed the significant statistical difference (p<0.001) (Figure 1A, 1B). This evidence concerns the gene LRP6 and adenoma.