FOXP3 and neoplasm: We found that the integrated optical density (IOD) of dark brown-stained Foxp3+ cells was significantly lower in the tumor centers in the treatment groups compared with the control group (p<0.001, p<0.001, p<0.001, respectively), while it was higher in the bronchus, adjacent to the tumor (p<0.001, p<0.001, p<0.001, respectively, Figure 4C).