There are 14 genes (including ZNF704, AKAP6, EXPH5, MFAP3L, MTURN, IPO7, TACC1, PTGER3, ZNF296, IGF1, WWC1, CGNL1, SH3BGRL2 and FAM54B) regulated by at least two miRNAs in the sub-network, many of which are involved in tumor progression and prognosis [24–29]. This evidence concerns the gene PTGER3 and neoplasm.