BCL2 and cancer: In conclusion, our study indicated for the first time that R7 derived from P. notoginseng exerts potent anti-tumor activity in HeLa cells by inhibiting cancer- associated PI3K/PTEN/Akt/mTOR activation.R7 targeted both PI3K (PTEN) and Akt, activating the pro-apoptotic Bcl-2 family and, subsequently, caspase family members (Figure 6).