CCNB1 and cervical cancer: Cyclin B1, a regulatory subunit of CDK1 and a crucial protein for the transition from G2 phase to mitosis of the cell cycle, is found to be overexpressed in invasive cervical cancer cells [78].The Human Papillomavirus E6 oncoprotein abolishes cell cycle checkpoints, inducing polyploidy, an early step in the carcinogenesis of cervical cancer. And the upregulation of CDK1 was observed in this process [79].