Given that the two prototypical adipokines (adiponectin and leptin) induce a number of opposing biological responses, further studies seeking to elucidate the molecular mechanisms underlying the differential role of the AMPK/FoxO3A axis between leptin- and adiponectin-induced modulation of tumor growth would be helpful for identification of promising pharmacological target molecules that could be useful in developing effective strategies for the treatment of cancer. Here, FOXO3 is linked to cancer.