FOXO3 and neoplasm: Given that the two prototypical adipokines (adiponectin and leptin) induce a number of opposing biological responses, further studies seeking to elucidate the molecular mechanisms underlying the differential role of the AMPK/FoxO3A axis between leptin- and adiponectin-induced modulation of tumor growth would be helpful for identification of promising pharmacological target molecules that could be useful in developing effective strategies for the treatment of cancer.