ChIPs 3 and 4 in both YAP1-interfered CD133+CD44+ CRC cell population and YAP1-enforced expressed CRC cells gave negative results, which indicated that both KLF5 and YAP1 bound to the first two loci that had a GC-box, but did not bind the other two loci. The gene discussed is YAP1; the disease is colorectal carcinoma.