YAP1 and malignant colon neoplasm: To further determine whether YAP1 could ensure the self-renewability of colon cancer progenitor cells, we established YAP1-enforced HT-29 (lv-YAP1/HT-29) and Caco-2 (lv-YAP1/Caco-2) cell lines with lentivirus particles using an LV5 (EF-1aF/GFP & Puro) vector with a YAP1 insert.