The proliferation rates of YAP1 interfered CD133+CD44+CRC cells were significantly decreased from days 3 to 4 (P<0.01), whereas, the proliferation rates of YAP1 interfered CD133-CD44- CRC cells significantly decreased at day 4 (P<0.01), and decreased at day 3 only in YAP1 interfered CD133-CD44- HT-29 cells (P<0.05). This evidence concerns the gene PROM1 and colorectal carcinoma.