YAP1 and colorectal carcinoma: Ascl2 regulation by YAP1 provided evidence that this Wnt target gene can also be transcriptionally activated by YAP1, an effector of Hippo signaling in CRC progenitor cells, and YAP1-activated Ascl2 expression in CRC progenitor cells controlled their cell state stability and conferred their ability to self-renewability.