Many studies have demonstrated a role of SAA in inflammatory diseases such as atherosclerosis [5] and rheumatoid arthritis [4], seemingly through control of different signaling pathways including NF-κB, JNK, C/EBP, JNK, Erk/MAPK and PI3k/Akt/mTor [6]. Here, MAPK8 is linked to rheumatoid arthritis.