Similar results could also be obtained in MCF7 cells transfected with another pair of shRNAs specifically against PKM2 (shPKM2#2) (Supplementary Figure 1A) and other shPKM2#1-transfected cancer cell lines such as A549 (Supplementary Figure 1C) and human leukemic NB4 cells (Supplementary Figure 1D). The gene discussed is PKM; the disease is cancer.