LEPR and esophageal squamous cell carcinoma: In male subgroup, after adjustment for age, smoking status, BMI and alcohol use, the LEPR rs6588147 AA genotype was associated with the increased risk of ESCC [AA vs. GG: adjusted OR = 2.19, 95% CI 1.02–4.67, P = 0.044 and AA vs. GA/GG: adjusted OR = 2.26, 95% CI 1.06–4.80, P = 0.035 (Table 6)].