In addition, LEPR rs1137101 G>A polymorphism decreased ESCC risk in some subgroups (ever smoking subgroup: GA vs. GG: adjusted OR=0.66, 95%CI=0.44–1.00, P=0.049; ever drinking subgroup: GA vs. GG: adjusted OR=0.54, 95%CI=0.31–0.95, P=0.031 and GA/AA vs. GG: adjusted OR=0.54, 95%CI=0.31–0.93, P=0.027). This evidence concerns the gene LEPR and esophageal squamous cell carcinoma.