When the LEPR rs6588147 GG/GA genotypes were used as the reference group, the LEPR rs6588147 AA genotype was associated with the increased risk of ESCC [AA vs. GG/GA: adjusted OR = 1.90, 95% CI = 1.00–3.61, P = 0.049 (Table 3)]. Here, LEPR is linked to esophageal squamous cell carcinoma.