However, in ever drinking subgroup, after adjustment for age, gender, smoking status and BMI, the LEPR rs6588147 GA genotype decreased the risk of ESCC [GA vs. GG: adjusted OR = 0.54, 95% CI 0.31–0.92, P = 0.024 (Table 6)]. Here, LEPR is linked to esophageal squamous cell carcinoma.