LEPR and esophageal squamous cell carcinoma: In ever drinking subgroup, after adjustment for gender, smoking status, BMI and age, we found that LEPR rs1137101 GA and GA/AA genotypes decreased the risk of ESCC [GA vs. GG: adjusted OR = 0.54, 95% CI 0.31–0.95, P = 0.031 and GA/AA vs. GG: adjusted OR = 0.54, 95% CI 0.31–0.93, P = 0.027 (Table 5)].