LEPR and esophageal squamous cell carcinoma: In <63 years subgroup, after adjustment for gender, smoking status, BMI and alcohol use, the LEPR rs6588147 AA genotype increased ESCC risk compared with the LEPR rs6588147 GG and GA/GG genotypes [AA vs. GG: adjusted OR = 2.58, 95% CI 1.00–6.62, P = 0.049 and AA vs. GA/GG: adjusted OR = 2.71, 95% CI 1.06–6.91, P = 0.038 (Table 6)].