However, we found that TCF7L2 rs7903146C>T, rs290481 T>C, LEP rs7799039 A>G, rs2167270 G>A and LEPR rs1137100 G>A, rs1137101 G>A polymorphisms were not associated with the development of overall ESCC (Table 3). Here, LEP is linked to esophageal squamous cell carcinoma.