LEP and esophageal squamous cell carcinoma: However, LEP rs7799039 A>G decreased the risk of ESCC (≥63 years subgroup: GG vs. AA: adjusted OR=0.47, 95%CI=0.23–0.95, P=0.035 and GG vs. AA/AG: adjusted OR=0.48, 95%CI=0.24–0.96, P=0.038; BMI≥24 kg/m2 subgroup: AG vs. AA: adjusted OR=0.66, 95%CI=0.45–0.99, P=0.044).