LEP and esophageal squamous cell carcinoma: In BMI ≥ 24 kg/m2 subgroup, after adjustment for age, gender, smoking status and alcohol use, we found that LEP rs7799039 AG genotype decreased the risk of ESCC [AG vs. AA: adjusted OR = 0.66, 95% CI 0.45–0.99, P = 0.044 (Table 4)].