LEP and esophageal squamous cell carcinoma: In ≥63 years subgroup, after adjustment for gender, smoking status, BMI and alcohol use, the LEP rs7799039 GG genotype decreased ESCC risk compared with the LEP rs7799039 AA genotype genotype or LEP rs7799039 AA/AG [GG vs. AA: adjusted OR = 0.47, 95% CI 0.23–0.95, P = 0.035 and GG vs. AA/AG: adjusted OR = 0.48, 95% CI = 0.24–0.96, P = 0.038 (Table 4)].