To examine the pathological relevance of G6PD in all RCCs development, the protein levels and cellular distribution of G6PD in RCC (60 ccRCC, 10 pRCC and 4 chRCC samples which were in parallel with the proportion of each RCC subtype) were analyzed using immunohistochemistry. The gene discussed is G6PD; the disease is nonpapillary renal cell carcinoma.