Interestingly, CM collected from adipocytes pre-incubated in HG (HG hAdipo-CM) increased by 2-fold CTGF expression levels in BC cells either compared to un-conditioned HG medium (p<0.01; Figure 5A) or compared to CM collected from adipocytes incubated in regular medium (hAdipo-CM; p<0.05; Figure 5A). Here, CCN2 is linked to breast cancer.