Upon multinomial logistic regression analysis (Table 3), PTCs with BRAF mutation alone showed significantly higher frequencies of extrathyroidal extension (odd ratio [OR] = 2.443, 95% confidence interval [CI] = 1.109–5.378), central lymph node metastasis (OR = 3.863, 95% CI = 1.417–10.531), hypoechogenicity (OR = 8.061, 95% CI = 2.994–21.705), and non-parallel orientation (OR = 4.098, 95% CI = 1.497-11.217) than PTCs without any mutation (Figures 1 and 2). Here, BRAF is linked to metastatic malignant neoplasm in the lymph nodes.