SMAP1 and neoplasm: We found that down regulation of each of 4 genes, i.e., SMAP1 (6q13), ZNF292 (6q14), HMGN3 (6q14), and UBE2J1 (6q15) significantly increased cell growth over background in colony formation assays performed in duplicate (P ≤ 0.0139, Figure 1 and Supplementary Figure 2), thus supporting a tumor suppressive role for these four genes.