Co-depletion of arbitrarily selected candidate tumor suppressor genes located inside the large 6q12-q22 deletion region identified 4 genes, including UBE2J1, ZNF292, SMAP1, and HMGN3 as a prime example for assumedly many more genes that jointly drive tumor growth when their activity is reduced by large heterozygous deletions. The gene discussed is HMGN3; the disease is neoplasm.