However, there was no correlation found between high HIF-1α expression and patient survival However very recently, the association of HIF-1α expression with clinicopathological characteristics and overall survival (OS) of patients with OSCC was evaluated by Zhou J et al. who found an association of HIF-1α overexpression with tumor size, tumor stage, lymph node metastasis, and overall survival [33]. This evidence concerns the gene HIF1A and metastatic malignant neoplasm in the lymph nodes.