FLT3 and leukemia: To test whether creno as single agent can induce cell death in FLT3-ITD driven Ba/F3 cells protected by stromal cells, we made use of an established in vitro co-culture system with the osteoblast-like murine embryonic cell line EL08-1D2 mimicking the BM niche and shown to effectively protect FLT3-ITD leukemia cells [9].