FLT3 and acute myeloid leukemia: To delineate in how far stromal protection of FLT3-ITD LIC is modulated by treatment, we evaluated the individual gene expression pattern by RNAseq of co-cultured FLT3-ITD/NPM1mut/DNMT3Amut PDX cells (AML sample #361, Table 2) with EL08-1D2 cells after in vitro treatment with DMSO, AZA, creno or the combination (Figure 8A).