FLT3 and leukemia: Creno was cytotoxic to murine Ba/F3 cells transduced with human FLT3-ITD (Ba/F3_FLT3-ITD) as well as FLT3-ITD human leukemia cell lines MV4-11 and MOLM-13 in a dose-dependent manner whereas no effect was observed on Ba/F3 cells transduced with FLT3 wild-type receptor (Ba/F3_FLT3-WT) or the leukemia cell line RS4;11 (Figure 2A, upper panel).