With increased liver fibrosis, the protein levels of α-smooth muscle actin (SMA), αv and β3 integrin subunits, and transforming growth factor-β1 (TGF-β1) were remarkably increased and were highest in the 9-week group (p < 0.05 for comparisons among all groups, Figure 6). Here, SMN1 is linked to Hepatic fibrosis.