EGFR and non-small cell lung carcinoma: Compared to their counterparts with the BIM wide-type, NSCLC cells expressing EGFR-mutant and harboring the BIM deletion polymorphism exhibited, a four-fold reduction on average in cell death when these cells were exposed to 10 uM erlotinib for long term (Figure 5C), indicating the vital importance of BIM in NSCLC cells expressing EGFR-mutant apoptosis induced by EGFR-TKIs.