First, our study demonstrated that TGF-β1 made hepatoma cells became mesenchymal cells and adopted a fibroblast-like morphology, and upregulated vimentin and fibronectin, downregulated E-cadherin significantly, which indicated that TGF-β1 could induce hepatoma cells occurs EMT (Figure 1). Here, TGFB1 is linked to hepatocellular carcinoma.