TGFB1 and hepatocellular carcinoma: Generally, our results indicated that curcumin downregulation the expression of Snail induced by TGF-β1 via inhibiting Smad2 phosphorylation and nuclear translocation, then suppressing the combination with the promoter of Snail to inhibit the transcription of Snail, which will inhibit the TGF-β1-induced EMT in hepatoma cells.