Generally, our results indicated that curcumin downregulation the expression of Snail induced by TGF-β1 via inhibiting Smad2 phosphorylation and nuclear translocation, then suppressing the combination with the promoter of Snail to inhibit the transcription of Snail, which will inhibit the TGF-β1-induced EMT in hepatoma cells. Here, SMAD2 is linked to hepatocellular carcinoma.