HIF-1α induces the expression of genes that trigger the tumor metabolic shift, promoting the increase of glucose uptake, the expression of glycolytic enzymes, the anaerobic glycolytic pathway of ATP generation,, and lactate production; it regulates pyruvate metabolism in both hypoxic and normoxic cells, increasing the production of precursors needed for cell growth [3, 6]. This evidence concerns the gene HIF1A and neoplasm.