PLOD1 and type 1 diabetes mellitus: In addition, we predicted 3 pathways including other glycan degradation, endocytosis and GnRH signaling pathway related to T1D, wherein the GnRH signaling pathway (Figure 5B) is a process that Gonadotropin-releasing hormone (GnRH) secreting from the hypothalamus acts upon its receptor in the anterior pituitary and increases the production and releases the gonadotropins containing LH and FSH [24].