There are 6 SLE specific pathways (Table 10), containing MAPK signaling pathway, calcium signaling pathway, renin-angiotensin system, RIG-I-like receptor signaling pathway, cytosolic DNA-sensing pathway and prostate cancer, they are signal pathways involved in regulating systemic and systemic vascular regulation, and these features are coincided with characteristics occurring SLE systemic. This evidence concerns the gene REN and systemic lupus erythematosus.