TGFB1 produces and controls immune cells by lymphocytes, macrophages and dendritic cells, and thus it becomes an important component on the pathogenesis of autoimmune diseases [14].In order to further understand the function of these genes and the relationship between them and the four diseases and also to explore the pathogenesis of the diseases, we used the online annotation tool DAVID (https://david.ncifcrf.gov/). The gene discussed is TGFB1; the disease is autoimmune disease.