The plots indicated that the HCC patients with a high expression of CDK5 had an inferior overall survival (OS; HR=1.697, 95% CI: 1.195-2.410, P=0.003) and disease-free survival (DFS; HR=1.351, 95% CI: 1.036-1.763, P=0.026) than those patients with a downregulated expression of CDK5. This evidence concerns the gene CDK5 and hepatocellular carcinoma.