The genomic region containing PAX8 is a common low penetrance susceptibility locus for mucinous ovarian cancer [10], and we recently identified PAX8 as a master regulator associated with susceptibility to serous ovarian cancer [11], suggesting that PAX8 may be a regulator of early EOC development and that transcriptional programs induced by PAX8 overexpression promote malignant transformation. This evidence concerns the gene PAX8 and ovarian serous adenocarcinoma.