While the precise mechanisms governing ADAM17- and EGFR-mediated protection against DSS-induced colitis remain unknown, the ErbB ligands and known ADAM17 substrates amphiregulin (AREG), epiregulin (EREG), and transforming growth factor (TGF)-α appear to be key effectors [8, 9, 13-15]. Here, AREG is linked to colitis.