These pathways represent processes involved in inflammatory pathways (e.g., cell adhesion molecules, JAK-STAT signaling pathway, intestinal immune network for IGA production), autoimmune response (e.g., type 1 diabetes, allograft rejection, graft versus host disease), and obesity-related comorbidities (e.g. type 2 diabetes, vascular smooth muscle contraction, cancer, and asthma). Here, SOAT1 is linked to obesity due to melanocortin 4 receptor deficiency.