INS and obesity due to melanocortin 4 receptor deficiency: Without the adjustment of obesity or BMI, we observed 148 significant associations (p < 0.05, Additional file 2: Table S3) with 39 for SBP, 45 for insulin, 1 for glucose, 14 for TG, 5 for TC, 25 for HDLC, and 19 for LDLC.