Similar synergistic effects on proliferation and apoptosis have been reported in pancreatic cancer, neuroblastoma, and AML cells by combination treatment using JQ1 with the pan-HDAC inhibitors SAHA (vorinostat) or panobinostat [8, 23, 24] and in melanoma cells by panobinostat and BET inhibitor I-BET151 [7]. The gene discussed is DNER; the disease is melanoma.