DNMT3A and hepatocellular carcinoma: In addition, overexpression of DNMT1, 3A, and 3B was correlated with tumorigenesis and other diseases (Qu et al., 2010; Rahman et al., 2010; Siddiqui et al., 2016), and DNMT3A expression was significantly associated with the prognosis of gastric and hepatocellular carcinomas in human (Oh et al., 2007; Cao et al., 2014).