C3 and retinopathy of prematurity: A strong association of gene variants involved in the complement pathway (CFH, CFB, C3), ECM remodeling (FBLN5, MMP9), leukocyte transendothelial migration and activation (CXCR4), HIF1A signaling and angiogenesis (ANGPT2, H2AFX, and VEGF), and developmental processes (TGFb1, IHH) observed in the present study (Table 1), confirms the involvement of genes in ROP pathogenesis.