Based on strong associations in the CFH and CFB genes, a quantitative assessment of a neurodegenerative panel containing CRP, SAP, MIP-4, Complement C4, apolipoprotein AI, apolipoprotein CIII, apolipoprotein E, Complement Factor H, and Complement C3 proteins was carried out by multiplex immuno-bead assay in the vitreous samples of ROP patients (n = 30) and controls (n = 30). This evidence concerns the gene CFH and retinopathy of prematurity.