The results of this experiment supported for shift in the proangiogenic state as demonstrated by a significant increase in the levels of cytokines IL8 (p = 0.0149), G-CSF (p = 0.0099), IL1ra (p = 0.0019), and VEGF (p = 0.0027) (Figures 1A,D) along with marginal increase of IL6, IL12, IL7, RANTES, and MCP1 in the ROP vitreous (data not shown). The gene discussed is IL6; the disease is retinopathy of prematurity.