In the present study, a strong association (p = 1.32 × 10−8) of rs2228014 in CXCR4 (Table 1) along with the presence of activated microglia/macrophages in the vitreous (Figure 1C), implicate their role in ROP angiogenesis via the leukocyte transendothelial migration. This evidence concerns the gene CXCR4 and retinopathy of prematurity.