To date, the information about changes in the expression of TLR and CLR during helminth infection is patchy at best, with the observations on TLR2 and TLR9 made in human patients with filarial disease and the effect of IL-4/IL-13 on Dectin-2 family CLR expression in human and mouse macrophages and DC treated in vitro. The gene discussed is DCLK3; the disease is helminthiasis.