Specifically, the myeloid-derived cytokines involved in the inflammatory response in DSS acute colitis iNOs, TNF-α, IL-6, IL-12, and the inflammasome drivers NLRP3 and IL-1β were enhanced in WT mice versus CD9−/− mice, but no differences were observed in either IFNγ, IL-17, or IL-22 cytokines. Here, TNF is linked to colitis.