TNFRSF11B and infection: In another study (99), OPG was used to treat mice induced to develop different types of cellular and humoral immune responses through: (1) infection with Mycobacterium bovis Bacillus Calmette and Guerin (BCG) followed by OPG-Fc treatment, (2) immunization with KLH in Freund’s adjuvant or by i.p. injection of a Pneumococcal Vaccine Polyvalent (Pneumovax®23, Merck) (3) immunization with Keyhole Limpet Hemocyanin (KLH) in vivo followed by OPG-Fc treatment, and (4) In a bid to induce contact hypersensitivity, mice were also sensitized with the hapten oxazolone, followed by treatment with OPG-Fc.