More recently, CHIT1 has been described as a prognostic biomarker for early MS (27, 28), and soluble GPNMB, which is secreted from different cell types through a disintegrin and metalloproteinase 10 sheddase activity, was identified as a further biomarker of Gaucher disease (29, 30). The gene discussed is GPNMB; the disease is Gaucher disease.