TKTL1 is a transketolase expressed by mature oligodendrocytes in PL-NAWM of MS lesions and by oligodendrocyte precursors, reactive astrocytes, and macrophages in the rim of MS lesions (48) that has been postulated to prevent neurodegeneration by reducing the formation of advanced glycation end products and radicals (49). This evidence concerns the gene TKTL1 and myeloid sarcoma.