Supporting the role of NF-κB in connecting whole-body metabolism with brain health, NF-κB overexpression in the hypothalamus-like pars intercerebralis neurons in Drosophila results in overnutrition, impaired metabolic learning, poor memory consolidation, and metabolic disorder characterized by increased lipid levels and shortened lifespan (57). Here, NFKB1 is linked to metabolic disease.