A second example is a phase II study of imalumab [BAX69, an anti-oxidized macrophage MIF (oxMIF)] and 5-FU/Leucovorin or Panitumumab (anti-EGRF mAb), versus the standard of care in metastatic colorectal cancer patients, which was terminated (February, 2017) based on overall benefit–risk assessment (NCT02448810), although it was initially reported that this combination was generally safe and well tolerated (355). The gene discussed is MIF; the disease is metastatic colorectal cancer.