Another example of vaccine therapy combines two anti-idiotipic antibodies, 11D10 (201) an mAb that mimics an epitope of the high molecular weight human milk fat globule glycoprotein, expressed at high levels by human breast and other tumor cells and 3H1 an mAb that mimics an epitope of the tumor-associated protein CEA (199). This evidence concerns the gene CEACAM5 and neoplasm.