Notably, the frequencies of seven HTNV GP nonapeptide-specific CD8+ T cells in the patients with mild/moderate disease were significantly higher than these in the patients with severe/critical disease and NC (p < 0.05, Figure 2B), indicating that the seven HTNV GP-derived epitopes might induce protective CTL responses in HLA-A*02+ HFRS patients. This evidence concerns the gene CD8A and hemorrhagic fever with renal syndrome.