Here, we demonstrated that seven HTNV GP-derived HLA-A*0201-restricted epitopes all could be recognized by the TCRs of CTLs in PBMCs of HFRS patients, indicating that these epitopes presented on HLA-A*02+ HTNV-infected cells may function as targets of specific CTLs. This evidence concerns the gene HLA-A and hemorrhagic fever with renal syndrome.