Multiple population studies have demonstrated that serum sCD40L concentrations were increased in MS patients with active disease compared to healthy controls (5.65 ± 2.87 vs. 0.14 ± 0.12 ng/mL, p < 0.001) or patients with inactive MS (5.65 ± 2.87 vs. 0.64 ± 0.30 ng/mL, p < 0.001) (31, 32). This evidence concerns the gene CD40LG and myeloid sarcoma.