SOAT1 and viral infectious disease: In this review, recent progress of canonical or non-canonical activation JAK/STAT pathway, viral antagonism of the JAK/STAT pathway, removing of the JAK/STAT antagonist from viral genome for virus attenuation, and the potential pathogenesis roles of tyrosine phosphorylation-independent non-canonical STATs activation during virus infection are discussed in detail to provide new insight to understand the interplay between JAK/STAT signaling and viral antagonism.