Global gene expression profiling revealed a significant downregulation of IFN-regulated signature genes in PBMCs of four patients with AE-IPF (Figure 2A; Table S2 in Supplementary Material) compared with healthy controls (HCs) and patients with stable IPF, suggesting that the STING signaling pathway may be impaired in AE-IPF. The gene discussed is IFNA1; the disease is idiopathic pulmonary fibrosis.