The ratio of phosphorylated IFN regulatory factor 3 (IRF3) to total IRF3 in the lung tissue of the mice treated with bleomycin and HSV-1 was increased by three times compared with that of the mice treated with saline and mock infection on day 7 after HSV-1 infection (day 21 after bleomycin injection) but remained unchanged on day 14 after HSV-1 infection (day 28 after bleomycin injection) (Figure S9 in Supplementary Material). The gene discussed is IRF3; the disease is infection.